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Deploy the B-Body ® platform for rapid discovery and robust developability, without compromise.
De-risk and accelerate bispecific antibody development
Speed to candidate
Accelerate discovery, reformatting, and screening with integrated workflows and high-throughput testing.
Derisked development
Increase success rate from discovery to development by eliminating reformatting risks.
CMC-ready candidates
Produce bispecifics with industry-leading expression and streamlined purification.
Plug & play compatible
Robustly reformat new or existing antibodies. Easy-to-trial platform with flexible testing access.
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B-Body® Bispecifics: Ultimate flexibility
for confidence in clinic
The answer to common bispecific challenges like light chain mispairing, instability, and low yield. Ready to use in final format and scalable manufacturing.
B-Body® Bispecific
A premier bispecific antibody framework engineered for exceptional yield, purity, and stability.
Explore an innovative framework that is optimized for yield and performance
- Unmatched bispecific yield
- Validated production in multiple commercial stable cell lines
- Proper assembly for heterodimerization for simple CMC
- 95% single-pass purity on CH1 or Protein A
- High solubility, stability, and low viscosity for formulation
Fc Region
Heavy-chain pairing with clinically-validated knobs-into-hole format.
Improve purity and yield
Reduce heavy-chain homodimers to increase the proportion of correctly assembled bispecific molecules.
De-risk manufacturing
Efficient assembly with a widely adopted strategy in therapeutic antibody development.
Fab Arm A
Prevent light-chain mispairing with rationally engineered Fab heterodimer.
Leverage proprietary CH3 domains
Replace CH1/CL on one Fab arm, driving correct pairing and ensuring proper light chain assembly on arm A.
Fab Arm B
Enhanced bispecific expression and purification.
Fab swap
Full Fab arm swap with disulfide lock.
Simplify purification
A single CH1 domain as well as pI asymmetry enables efficient purification in high throughput as well as larger scales.
Sole CH1 Domain
A powerful purification step beyond standard protein A/IEX.
Enable one-step purification
Simplify downstream processing during characterization and screening with a sole CH1 domain that facilitates purification using an anti-CH1 resin.
Services
Support at every stage of your bispecific development
Antibody Discovery
Discover bispecific-ready antibodies from the start. Design campaigns that reduce downstream engineering and improve success rates.
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Antibody Production and Characterization
Rapidly generate and test bispecific formats. Plug existing mAbs into high-throughput bispecific screening workflows.
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Antibody Optimization
Advance developable bispecific candidates. Select candidates expressed directly in final format to streamline development.
ExploreLet data drive your decisions
99%
Compatibility
Reformatting success
~200mg/mL
Formulation
Without viscosity limitation
>10g/L
Expression
Yield in stable CHO production
12+
Biopharma licensees
B-Body Bispecific biologics
Partner companies using B-Body Bispecifics
Technical documents
Explore the B-Body platform in depth with these resources.
Product Sheets
B-Body Bispecific Platform Product SheetService Sheets
B-Body Bispecific Antibody Production Service SheetSlide Decks
B-Body Bispecific Antibody Discovery Capabilities and Case StudyFor Research Use Only.
Not for Diagnostic Procedures.
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681 Gateway Blvd
South San Francisco, CA 94080
